Comprehensive Review of Pharmacology for the Anesthesia Written Boards

Pharmacologic Principles

  • Pharmacokinetics, -dynamics, Protein Binding, Partition Coefficients, Pka
    Ionization, Tissue Uptake, Compartmentalization and Exponential Models
  • Pharmacokinetics of Neuraxial Drug Administration: Epidural and Subarachnoid
  • Tolerance and Tachyphylaxis
  • Elimination; Biotransformation, Context-Sensitive Half-Time
  • Impact of Renal, Liver Disease
  • Enzyme Induction and Inhibition
  • Hepatic Blood Flow
  • Drug-Drug Binding
  • Alternative and Herbal Medicines: Perioperative Implications
  • Drug Reactions (Anaphylactoid, Anaphylaxis, Idiosyncratic)

Anesthetics-Gases and Vapors

  • Physical Properties
  • Mechanism of Action
  • Effects on Central Nervous System (CNS), Cardiovascular System, Respiration, Neuromuscular Function, Renal Function, Hepatic Function, Hematologic and Immune Systems
  • Biotransformation and Toxicity
  • Minimum Alveolar Concentration (MAC), Factors Affecting MAC
  • Trace Concentrations, OR Pollution, Personnel Hazards

Intravenous Agents

  • Mechanism of Action
  • Pharmacokinetics and Pharmacodynamics
  • Epidural and Intrathecal
  • Effect on Circulation, Respiration, Other Organs
  • Side Effects and Toxicity
  • Indications and Contraindications
  • Barbituates, Propofol, Etomidate, Benzodiazepines, Ketamine
  • Local Anesthetic Uptake, Mechanism of Action, Biotransformation and Excretion, Comparison of Drugs and Chemical Groups, Prolongation of Action, Side Effects and Toxicity, Seizures, Cauda Equina Syndrome, Transient Neurological Symptom, Cardiac, Allergy, Preservatives/Additives, Methemoglobinemia
  • Muscle Relaxants (Depolarizing, Non-Depolarizing), Mechanism of Action, Pharmacokinetics and Pharmacodynamics, Abnormal Responses, Prolongation of Action; Synergism, Metabolism and Excretion, Side Effects and Toxicity, Indications and Contraindications, Antagonism of Blockade, Drug Interactions (Antibiotics, Antiepileptics, Lithium, Magnesium, Inhalational Anesthetics)
Course Information
Dr. Michael Ho
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